Drug interactions diet - grapefruit - nil
This document is part of the ACI Diet Specifications for Adult Inpatients. It is not to be used for patient education.
Aim
To provide a diet without any grapefruit or grapefruit products.
Characteristics
Avoids grapefruit and any foods containing grapefruit products.
Indications
Patients prescribed drugs that are metabolised by the cytochrome P450 enzymes (CYP3A4) and P-glycoprotein (Pgp) in enterocytes in the intestinal wall. These drugs include calcium channel blockers (felodipine, nifedipine), HMG–CoA reductase inhibitors (simvastatin, atorvastatin), benzodiazepines (midazolam, triazolam), cyclosporin, saquinavir and cisapride.
Nutritional adequacy
Nutritionally adequate.
Precautions
None.
Paediatrics
Suitable for use in paediatrics when combined with an age-appropriate diet.
Specific menu planning guidelines
| Allowed | Not allowed | |
|---|---|---|
| Hot main dishes | All others | Dishes with added grapefruit |
| Sauces, gravies | All | - |
| Starchy vegetables / pasta / rice | All | - |
| Vegetables | All | - |
| Soups | All | - |
| Sandwiches | All | - |
| Salads, dressings | All others | No grapefruit pieces or juices |
| Breads, cereals | All | - |
| Spreads | All others | Marmalade with grapefruit |
| Hot breakfast choices | All | - |
| Fruit | All other fruit | Grapefruit |
| Yoghurt | All others yoghurts | Any yoghurt containing grapefruit |
| Desserts | All | - |
| Milk and cheese | All | - |
| Beverages | Tea, coffee, cordial, other juices | Grapefruit juice |
| Biscuits | All | - |
| Miscellaneous | Other citrus fruit | Citrus peel |
References
- Adverse Drug Reactions Advisory Committee (ADRAC). Interactions with grapefruit juice. Aust Adv Drug Reactions Bull 2002;21(4). [accessed 06 June 2023].
- McNeece J. Grapefruit juice interactions. Aust Prescr 2002;25(2):37.