Fact sheetDiet specifications

Published on 1 Nov 2011


Drug interactions diet - grapefruit - nil

This document is part of the ACI Diet Specifications for Adult Inpatients. It is not to be used for patient education.

Aim

To provide a diet without any grapefruit or grapefruit products.

Characteristics

Avoids grapefruit and any foods containing grapefruit products.

Indications

Patients prescribed drugs that are metabolised by the cytochrome P450 enzymes (CYP3A4) and P-glycoprotein (Pgp) in enterocytes in the intestinal wall. These drugs include calcium channel blockers (felodipine, nifedipine), HMG–CoA reductase inhibitors (simvastatin, atorvastatin), benzodiazepines (midazolam, triazolam), cyclosporin, saquinavir and cisapride.

Nutritional adequacy

Nutritionally adequate.

Precautions

None.

Paediatrics

Suitable for use in paediatrics when combined with an age-appropriate diet.

Specific menu planning guidelines

Allowed Not allowed
Hot main dishesAll othersDishes with added grapefruit
Sauces, graviesAll-
Starchy vegetables / pasta / riceAll-
VegetablesAll-
SoupsAll-
SandwichesAll-
Salads, dressingsAll othersNo grapefruit pieces or juices
Breads, cerealsAll-
SpreadsAll othersMarmalade with grapefruit
Hot breakfast choicesAll-
FruitAll other fruitGrapefruit
YoghurtAll others yoghurtsAny yoghurt containing grapefruit
DessertsAll-
Milk and cheeseAll-
BeveragesTea, coffee, cordial, other juicesGrapefruit juice
BiscuitsAll-
MiscellaneousOther citrus fruitCitrus peel

References

  1. Adverse Drug Reactions Advisory Committee (ADRAC). Interactions with grapefruit juice. Aust Adv Drug Reactions Bull 2002;21(4). [accessed 15 May 2010].
  2. McNeece J. Grapefruit juice interactions. Aust Prescr 2002;25(2):37.
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