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Phosphate - Hyperphosphataemia

This content is under review.

Hyperphosphatemia often occurs in association with low calcium precipitation of phosphate with the calcium in tissues. Average phosphorus levels should be between 0.81 mmol/L and 1.45 mmol/L.

Causes of hyperphosphatemia

  • Renal insufficiency

    • ?Hypoparathyroidism

  • Parathyroid suppression

  • Severe hypermagnesemia or hypomagnesemia

    • Pseudohypoparathyroidism

    • Acromegaly

    • Tumoral calcinosis

    • Heparin therapy

Massive extracellular fluid phosphate loads

  • Rapid administration of exogenous phosphate (intravenous, oral, rectal)

  • Extensive cellular injury or necrosis

    • Crush injuries

    • Rhabdomyolysis

    • Hyperthermia

    • Fulminant hepatitis

    • Cytotoxic therapy

    • Severe hemolytic anemia

  • ?Transcellular phosphate shifts

    • Metabolic acidosis

    • Respiratory acidosis

Management

High phosphate levels are avoided with phosphate binders and dietary restriction of phosphate.

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