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Phosphate - Hyperphosphataemia
This content is under review.
Hyperphosphatemia often occurs in association with low calcium precipitation of phosphate with the calcium in tissues. Average phosphorus levels should be between 0.81 mmol/L and 1.45 mmol/L.
Causes of hyperphosphatemia
Renal insufficiency
?Hypoparathyroidism
Parathyroid suppression
Severe hypermagnesemia or hypomagnesemia
Pseudohypoparathyroidism
Acromegaly
Tumoral calcinosis
Heparin therapy
Massive extracellular fluid phosphate loads
Rapid administration of exogenous phosphate (intravenous, oral, rectal)
Extensive cellular injury or necrosis
Crush injuries
Rhabdomyolysis
Hyperthermia
Fulminant hepatitis
Cytotoxic therapy
Severe hemolytic anemia
?Transcellular phosphate shifts
Metabolic acidosis
Respiratory acidosis
Management
High phosphate levels are avoided with phosphate binders and dietary restriction of phosphate.
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