Fibrinogen administration in prehospital trauma

Fibrinogen concentrate is freeze dried fibrinogen, a vital clotting factor.

This evidence report considers if fibrinogen concentrate is a reasonable alternative to allogeneic products in the pre-hospital setting. It examines the literature regarding patient mortality, intensive care unit length of stay, safety, need for additional blood products, storage, administration and costs.

Download the evidence report (PDF 683.5 KB)

Key points from the report:

• Current published evidence is low quality.
• Suggests fibrinogen concentrate in hospital setting is safe and effective.
• There are logistic advantages for fibrinogen concentrate with storage, preparation and more rapid administration.

Outcome

In the absence of allogenic products, fibrinogen concentrate could be considered as a reasonable pre-hospital alternative. This is best conducted under clinical trial conditions.