Truths about progressive resistance training

Progressive resistance training reduces pain and improves mobility in people with osteoarthritis in their hips and knees.

Specific resistance training before and after joint replacement improves recovery and functional outcomes.

There is no evidence to suggest that progressive resistance training will exacerbate knee osteoarthritis.

References
  • Calatayud J, Casaña J, Ezzatvar Y, et al. High-intensity preoperative training improves physical and functional recovery in the early post-operative periods after total knee arthroplasty: a randomized controlled trial. Knee Surg Sports Traumatol Arthrosc. 2017;25(9):2864-2872. DOI: 10.1007/s00167-016-3985-5
  • Foroughi N, Smith RM, Lange AK, et al. Progressive resistance training and dynamic alignment in osteoarthritis: A single-blind randomised controlled trial. Clin Biomech. 2011;26(1):71-77. DOI: 10.1016/j.clinbiomech.2010.08.013
  • Liao CD, Chen HC, Kuo YC, et al. Effects of muscle strength training on muscle mass gain and hypertrophy in older adults with osteoarthritis: a systematic review and meta-analysis. Arthritis Care Res (Hoboken). 2020;72(12):1703-1718. DOI: 10.1002/acr.24097
  • Moyer R, Ikert K, Long K, et al. The value of preoperative exercise and education for patients undergoing total hip and knee arthroplasty. JBJS Rev. 2017;5(12): e2-e2. DOI: 10.2106/JBJS.RVW.17.00015
  • Turner MN, Hernandez DO, Cade W, et al. The role of resistance training dosing on pain and physical function in individuals with knee osteoarthritis: a systematic review. Sports Health. 2020;12(2):200-206. DOI: 10.1177/1941738119887183
  • Wen Z, Chai Y. Effectiveness of resistance exercises in the treatment of rheumatoid arthritis: A meta-analysis. Medicine. 2021;100(13):e25019. DOI: 10.1097/MD.0000000000025019

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Progressive resistance training prevents and treats coronary artery disease and treats chronic heart failure.

References
  • Hollings M, Mavros Y, Freeston J, et al. The effect of progressive resistance training on aerobic fitness and strength in adults with coronary heart disease: A systematic review and meta-analysis of randomised controlled trials. Eur J Prev Cardiol. 2017;24(12):1242-1259. DOI: 10.1177/2047487317713329
  • Jewiss D, Ostman C, Smart NA. The effect of resistance training on clinical outcomes in heart failure: A systematic review and meta-analysis. Int J Cardiol. 2016;221:674-681. DOI: 10.1016/j.ijcard.2016.07.046
  • Lee J, Lee R, Stone AJ. Combined aerobic and resistance training for peak oxygen uptake, muscle strength, and hypertrophy after coronary artery disease: a systematic review and meta-analysis. J Cardiovasc Transl Res. 2020;13(4):601-611. DOI: 10.1007/s12265-019-09922-0
  • Ruku DM, Tran Thi TH, Chen HM. Effect of center-based or home-based resistance training on muscle strength and VO2 peak in patients with HFrEF: A systematic review and meta-analysis. Enferm Clin (Engl Ed). 2021;S1130-8621(21)00040-1. DOI: 10.1016/j.enfcli.2021.01.011.
  • Vincent KR, Vincent HK. Resistance training for individuals with cardiovascular disease. J Cardiopulm Rehabil. 2006;26(4):207-218. DOI: 10.1097/00008483-200607000-00002
  • Williams MA, Haskell WL, Ades PA, et al. Resistance exercise in individuals with and without cardiovascular disease: 2007 update: a scientific statement from the American Heart Association Council on Clinical Cardiology and Council on Nutrition, Physical Activity, and Metabolism. Circulation. 2007;116(5):572-584. DOI: 10.1161/CIRCULATIONAHA.107.185214

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Progressive resistance training maintains or increases bone density. Along with balance training, it may prevent falls and fractures in people living with osteoporosis.

Progressive resistance training improves recovery, independent living and reduces mortality after hip fracture as part of a multidisciplinary program targeting frailty components.

References
  • Beck BR, Daly RM, Singh MA, et al. Exercise and Sports Science Australia (ESSA) position statement on exercise prescription for the prevention and management of osteoporosis. J Sci Med Sport. 2017;20(5):438-445. DOI: 10.1016/j.jsams.2016.10.001
  • Kitsuda Y, Wada T, Noma H, et al. Impact of high-load resistance training on bone mineral density in osteoporosis and osteopenia: a meta-analysis. J Bone Miner Metab. 2021;39(5):787-803. DOI: 10.1007/s00774-021-01218-1
  • Ponzano M, Rodrigues IB, Hosseini Z, et al. Progressive resistance training for improving health-related outcomes in people at risk of fracture: a systematic review and meta-analysis of randomized controlled trials. Phys Ther. 2021;101(2):pzaa221. DOI: 10.1093/ptj/pzaa221
  • Singh NA, Quine S, Clemson LM, et al. Effects of high-intensity progressive resistance training and targeted multidisciplinary treatment of frailty on mortality and nursing home admissions after hip fracture: a randomized controlled trial. J Am Med Dir Assoc. 2012;13(1):24-30.

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Progressive resistance training can be performed at home with minimal, inexpensive equipment, such as resistance bands, ankle weights and dumbbells or by using your own body weight as resistance.

To get the best strength and mobility outcomes, participate in some level of in-person or remotely supervised resistance exercise. Also, use equipment that allows you to progress and increase the intensity of your exercise.

References
  • Billany RE, Vadaszy N, Lightfoot CJ, et al. Characteristics of effective home-based resistance training in patients with noncommunicable chronic diseases: a systematic scoping review of randomised controlled trials. J Sports Sci. 2021;39(10):1174-1185. DOI: 10.1080/02640414.2020.1861741
  • Mañas A, Gómez-Redondo P, Valenzuela PL, et al. Unsupervised home-based resistance training for community-dwelling older adults: a systematic review and meta-analysis of randomized controlled trials. Ageing Res Rev. 2021;69:101368. DOI: 10.1016/j.arr.2021.101368

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We should all lift weights, no matter our age.

Advancing age and muscle weakness can lead to frailty. They are some of the most important reasons to start progressive resistance training. The weaker you are when you start, the greater your relative benefits will be from strength training.

References
  • Fragala MS, Cadore EL, Dorgo S, et al. Resistance training for older adults: position statement from the National Strength and Conditioning Association. J Strength Cond Res. 2019;33(8):2019-2052. DOI: 10.1519/JSC.0000000000003230
  • Nagai K, Miyamato T, Okamae A, et al. Physical activity combined with resistance training reduces symptoms of frailty in older adults: A randomized controlled trial. Arch Gerontol Geriatr. 2018;76:41-47. DOI: 10.1016/j.archger.2018.02.005
  • Talar K, Hernandez-Belmonte A, Vetrovsky T, et al. Benefits of Resistance training in early and late stages of frailty and sarcopenia: a systematic review and meta-analysis of randomized controlled studies. J Clin Med. 2021;10(8):1630. DOI: 10.3390/jcm10081630
  • Valenzuela T. Efficacy of progressive resistance training interventions in older adults in nursing homes: a systematic review. J Am Med Dir Assoc. 2012;13(5):418-428. DOI: 10.1016/j.jamda.2011.11.001

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Progressive resistance training can be performed safely and effectively whilst seated.

Strength training, particularly when combined with balance exercise, decreases falls and reduces fear of falling.

References
  • Fragala MS, Cadore EL, Dorgo S, et al. Resistance training for older adults: position statement from the National Strength and Conditioning Association. J Strength Cond Res. 2019;33(8):2019-2052. DOI: 10.1519/JSC.0000000000003230
  • Hewitt J, Goodall S, Clemson L, et al. Progressive resistance and balance training for falls prevention in long-term residential aged care: a cluster randomized trial of the Sunbeam program. J Am Med Dir Assoc. 2018;19(4):361-369. DOI: 10.1016/j.jamda.2017.12.014
  • Howe TE, Rochester L, Neil F, et al. Exercise for improving balance in older people. Cochrane Database Syst Rev. 2011;(11):CD004963. DOI: 10.1002/14651858.CD004963.pub3
  • Keating CJ, Cabrera-Linares JC, Párraga-Montilla JA, Let al. Influence of resistance training on gait & balance parameters in older adults: a systematic review. Int J Environ Res Public Health. 2021;18(4):1759. DOI: 10.3390/ijerph18041759
  • Lacroix A, Hortobágyi T, Beurskens R, et al. Effects of supervised vs. unsupervised training programs on balance and muscle strength in older adults: a systematic review and meta-analysis. Sports Med. 2017;47(11):2341-2361. DOI: 10.1007/s40279-017-0747-6

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Progressive resistance training is effective in treating virtually all chronic diseases, including those contributing to frailty, such as depression, cognitive decline, mobility impairment, cardiometabolic disease, pulmonary disease, cerebrovascular disease and degenerative neurological conditions.

References
  • Fragala MS, Cadore EL, Dorgo S, et al. Resistance training for older adults: position statement from the National Strength and Conditioning Association. J Strength Cond Res. 2019;33(8):2019-2052. DOI: 10.1519/JSC.0000000000003230
  • Izquierdo M, Merchant RA, Morley JE, et al. International exercise recommendations in older adults (ICFSR): expert consensus guidelines. J Nutr Health Aging. 2021;25(7):824-853. DOI: 10.1007/s12603-021-1665-8

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Your muscles will only get significantly stronger with specific resistance exercises at an intensity that challenges them more than your usual day-to-day activities.

Walking is great for general mobility, but that will not help frailty if it is related to weakness. Walking will not increase your muscle strength or muscle mass.

Exercise programs combining resistance and balance training help to treat symptoms associated with frailty, help to reduce falls and maintain health benefits.

References
  • American College of Sports Medicine, Chodzko-Zajko WJ, Proctor DN, et al. American College of Sports Medicine position stand. Exercise and physical activity for older adults. Med Sci Sports Exerc. 2009;41(7):1510-1530. DOI: 10.1249/MSS.0b013e3181a0c95c
  • Dent E, Lien C, Lim WS, et al. The Asia-Pacific Clinical practice guidelines for the management of frailty. J Am Med Dir Assoc. 2017;18(7):564-575. DOI: 10.1016/j.jamda.2017.04.018
  • Kidd T, Mold F, Jones C, et al. What are the most effective interventions to improve physical performance in pre-frail and frail adults? A systematic review of randomised control trials. BMC Geriatr. 2019;19(1):184. DOI: 10.1186/s12877-019-1196-x

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Muscles will only get stronger with specific, targeted, resistance training at an intensity that challenges them more than your usual daily activities.

References
  • Dent E, Lien C, Lim WS, et al. The Asia-Pacific Clinical practice guidelines for the management of frailty. J Am Med Dir Assoc. 2017;18(7):564-575. DOI:10.1016/j.jamda.2017.04.018

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Fatigue related to sleep apnoea or depression can be addressed with resistance exercise.

Fatigue can be improved through exercises.

While long periods of aerobic exercise may cause fatigue, resistance training only requires a small amount of time. It only takes a few minutes to train each muscle group.

References
  • Kovacevic A, Mavros Y, Heisz JJ, et al. The effect of resistance exercise on sleep: A systematic review of randomized controlled trials. Sleep Med Rev. 2018;39:52-68. DOI:10.1016/j.smrv.2017.07.002
  • Sahin UK, Kirdi N, Bozoglu E, et al. Effect of low-intensity versus high-intensity resistance training on the functioning of the institutionalized frail elderly. Int J Rehabil Res. 2018;41(3):211-217. DOI:10.1097/MRR.0000000000000285

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Progressive resistance training refers to a progressive resistance that challenges your muscles to make them become stronger.

The term ‘strength training’ is more commonly used, but ‘resistance training’ is preferred.

Progressive resistance training refers to progressively adding resistance to your muscles so that they become stronger.

It’s important to do progressive resistance training throughout your life, especially as we get older as our muscles start to lose their strength.

References
  • Fragala MS, Cadore EL, Dorgo S, et al. Resistance training for older adults: position statement from the National Strength and Conditioning Association. J Strength Cond Res. 2019;33(8):2019-2052. DOI:10.1519/JSC.0000000000003230

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The ‘Healthy Eating to Stay Strong and Independent’ document recommends that older adults:

  • have about 1-1.2g of protein per kg of body weight, per day
  • eat at least 20-30g of protein by including protein-rich foods at each mealtime
  • eat a high protein meal or snack 20-30 minutes after your exercise.
Requirements may vary based on your medical conditions. A higher protein diet may be recommended if you are acutely unwell or have a protein energy malnutrition. If you are unsure of your protein requirements, speak to an accredited practicing dietitian or your general practioner.

References
  • Bauer J, Biolo G, Cederholm T, et al. Evidence-based recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE study group. J Am Med Dir Assoc 2013; 14:542-59. DOI: 10.1016/j.jamda.2013.05.021
  • Deutz NE, Bauer JM, Barazzoni R, et al. Protein intake and exercise for optimal muscle function with aging: recommendations from the ESPEN Expert Group. Clin Nutr. 2014;33(6):929-936. DOI:10.1016/j.clnu.2014.04.007
  • Morton RW, Murphy KT, McKellar SR, et al. A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults. Br J Sports Med. 2018;52(6):376-384. DOI:10.1136/bjsports-2017-097608
  • NSW Agency for Clinical Innovation. Healthy eating to stay strong and independent [internet]. Sydney: ACI; 2022.

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If you have protein-energy malnutrition, adequate energy and protein intake combined with progressive resistance training will help.

It is important to do progressive resistance training because it can help increase your appetite and prevent you from losing muscle (which is called sarcopenia) that occurs from malnutrition.

Your nutrition needs and your appetite are linked to how much muscle mass you have, so maintaining or increasing your muscle mass with progressive resistance training can encourage you to eat more.

There is some evidence that the benefits of progressive resistance training are increased with protein or nutrition supplementation, particularly if you are undernourished, but further studies are required.

References
  • O'Bryan KR, Doering TM, Morton RW, Coffey VG, Phillips SM, Cox GR. Do multi-ingredient protein supplements augment resistance training-induced gains in skeletal muscle mass and strength? A systematic review and meta-analysis of 35 trials. Br J Sports Med. 2020;54(10):573-581. DOI:10.1136/bjsports-2018-099889
  • Hou L, Lei Y, Li X, et al. Effect of protein supplementation combined with resistance training on muscle mass, strength and function in the elderly: a systematic review and meta-analysis. J Nutr Health Aging. 2019;23(5):451-458. DOI:10.1007/s12603-019-1181-2

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Progressive resistance training has proven efficacy and safety in the treatment of virtually all chronic diseases, including those contributing to frailty, such as depression, cognitive decline, mobility impairment, cardiometabolic disease, pulmonary disease, cerebrovascular disease and degenerative neurological conditions. Low rates of adverse events have been reported in clinical trials of progressive resistance training. Walking has been associated with increased falls and fractures, whereas progressive resistance training combined with balance exercises is protective. Progressive resistance training is associated with a lower risk of cardiovascular events than aerobic exercise.

To be most effective, exercise should be prescribed for the underlying impairment being addressed (e.g. sarcopenia, balance or neurological impairment). It is important to ensure the specificity of practice is evidence-based and to prescribe progressive muscle overload to ensure adaptation occurs. Prescribing functional type exercises may not be the most appropriate. Prescribe progressive muscle overload to address the sarcopenia, and prescribe balance training for the balance deficits.

Get up (resistance training). Stay up (balance training). Keep moving (aerobic training).

Three times per week of progressive resistance training is optimal and 1-2 days per week is also beneficial. Progressive resistance training can be delivered in ways other than just clinician-supervised, provided that the specificity of prescription is appropriate (e.g. semi-supervised, independent or group exercise).

Progressive resistance training can be prescribed in any healthcare or community setting (e.g. hospital, outpatient clinic, residential aged care, dialysis units, community centres or homes) using machines, free weights, elastic bands or simply body weight. The best outcomes are achieved when resistance is measurable, high intensity, and progressive with training supervised.

Low intensity, non-progressive exercise does not cause the adaptations needed to improve strength, function, mobility, or any chronic diseases. These outcomes are the motivational reasons to promote evidence-based modalities and dosages of exercise. The outcomes can motivate people patients to move out of their comfort zone and progress their exercise from mobility and gentle exercises.

There is no evidence that gentle or range of motion exercises prevent or treat any chronic diseases or geriatric syndromes such as sarcopenia or frailty. Using medications that have been shown to be ineffective would be considered inappropriate and below clinical standard of care. The same principle applies to exercise prescription.

There is evidence that fatigue in people who have sleep apnoea or depression can be addressed through progressive resistance training. Fatigue associated with exercise is often related to long and intense periods of exercise, however, progressive resistance training requires far less time. Those with the lowest levels of fitness improve the most in relative terms when adopting progressive resistance training.

References

  • American College of Sports Medicine, Chodzko-Zajko WJ, Proctor DN, et al. American College of Sports Medicine position stand. Exercise and physical activity for older adults. Med Sci Sports Exerc. 2009;41(7):1510-1530. DOI: 10.1249/MSS.0b013e3181a0c95c
  • Cameron ID, Fairhall N, Langron C, et al. A multifactorial interdisciplinary intervention reduces frailty in older people: randomized trial. BMC Med. 2013;11:65. Published 2013 Mar 11. DOI: 10.1186/1741-7015-11-65
  • Dent E, Lien C, Lim WS, et al. The Asia-Pacific clinical practice guidelines for the management of frailty. J Am Med Dir Assoc. 2017 Jul 1;18(7):564-75. DOI: 10.1016/j.jamda.2017.04.018
  • El-Kotob R, Ponzano M, Chaput JP, et al. Resistance training and health in adults: an overview of systematic reviews. Appl Physiol Nutr Metab. 2020;45(10 (Suppl. 2)):S165-S179. DOI: 10.1139/apnm-2020-0245
  • Fragala MS, Cadore EL, Dorgo S, et al. Resistance training for older adults: position statement from the National Strength and Conditioning Association. J Strength Cond Res. 2019;33(8):2019-2052. DOI: 10.1519/JSC.0000000000003230
  • Grgic J, Garofolini A, Orazem J, et al. Effects of resistance training on muscle size and strength in very elderly adults: a systematic review and meta-analysis of randomized controlled trials. Sports Med. 2020;50(11):1983-1999. DOI: 10.1007/s40279-020-01331-7
  • I Izquierdo M, Merchant RA, Morley JE, et al. International exercise recommendations in older adults (ICFSR): expert consensus guidelines. J Nutr Health Aging. 2021;25(7):824-53. DOI: 10.1007/s12603-021-1665-8
  • Jukic I, Ramos AG, Helms ER, et al. Acute effects of cluster and rest redistribution set structures on mechanical, metabolic, and perceptual fatigue during and after resistance training: a systematic review and meta-analysis. Sports Med.2020;50(12):2209-2236. DOI: 10.1007/s40279-020-01344-2
  • Mierzwicki JT, Fox MA, Griffith KR, et al. Comparison of high-intensity resistance and power training programs in pre-frail and frail older adults. Phys Occup Ther. 2020;38(3):271-82. DOI: 10.1080/02703181.2020.1748161
  • Keating CJ, Cabrera-Linares JC, Párraga-Montilla JA, et al. Influence of resistance training on gait & balance parameters in older adults: a systematic review. Int J Environ Res Public Health. 2021 Feb 11;18(4). DOI: 10.3390/ijerph18041759
  • Keenan S, Cooke MB, Belski R. The effects of intermittent fasting combined with resistance training on lean body mass: a systematic review of human studies. Nutrients. 2020;12(8):2349. DOI: 10.3390/nu12082349
  • Kidd T, Mold F, Jones C, et al. What are the most effective interventions to improve physical performance in pre-frail and frail adults? A systematic review of randomised control trials. BMC Geriatr. 2019 Jul 11;19(1):184. DOI: 10.1186/s12877-019-1196-x
  • Kis O, Buch A, Stern N, Moran DS. Minimally supervised home-based resistance training and muscle function in older adults: A meta-analysis. Arch Gerontol Geriatr. 2019;84:103909. DOI: 10.1016/j.archger.2019.103909
  • Labata-Lezaun N, Llurda-Almuzara L, López-de-Celis C, et al. Effectiveness of protein supplementation combined with resistance training on muscle strength and physical performance in elderly: a systematic review and meta-analysis. Nutrients. 2020 Aug 27;12(9). DOI: 10.3390/nu12092607
  • Lacroix A, Hortobágyi T, Beurskens R, et al. Effects of supervised vs. unsupervised training programs on balance and muscle strength in older adults: a systematic review and meta-analysis. Sports Med. 2017 Nov;47(11):2341-61. DOI: 10.1007/s40279-017-0747-6
  • Lopez P, Radaelli R, Taaffe DR, et al. Resistance Training load effects on muscle hypertrophy and strength gain: systematic review and network meta-analysis. Med Sci Sports Exerc. 2021;53(6):1206-1216. DOI: 10.1249/MSS.0000000000002585
  • Mañas A, Gómez-Redondo P, Valenzuela PL, et al. Unsupervised home-based resistance training for community-dwelling older adults: A systematic review and meta-analysis of randomized controlled trials. Ageing Res Rev. 2021 Aug;69:101368. DOI: 10.1016/j.arr.2021.101368
  • Morton RW, Murphy KT, McKellar SR, et al. A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults. Br J Sports Med. 2018 Mar;52(6):376-84. DOI: 10.1136/bjsports-2017-097608
  • O'Bryan KR, Doering TM, Morton RW, et al. Do multi-ingredient protein supplements augment resistance training-induced gains in skeletal muscle mass and strength? A systematic review and meta-analysis of 35 trials. Br J Sports Med. 2020 May;54(10):573-81. DOI: 10.1136/bjsports-2018-099889
  • Polito MD, Papst RR, Farinatti P. Moderators of strength gains and hypertrophy in resistance training: A systematic review and meta-analysis. J Sports Sci. 2021;39(19):2189-2198. DOI: 10.1080/02640414.2021.1924978
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  • Thomas E, Gentile A, Lakicevic N, et al. The effect of resistance training programs on lean body mass in postmenopausal and elderly women: a meta-analysis of observational studies. Aging Clin Exp Res. 2021;33(11):2941-2952. DOI: 10.1007/s40520-021-01853-8

  • Cordner T, Egerton T, Schubert K, et al. Ballistic Resistance training: feasibility, safety, and effectiveness for improving mobility in adults with neurologic conditions: a systematic review. Arch Phys Med Rehabil. 2021;102(4):735-751. DOI: 10.1016/j.apmr.2020.06.023
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  • Li Z, Peng X, Xiang W, et al. The effect of resistance training on cognitive function in the older adults: a systematic review of randomized clinical trials. Aging Clin Exp Res. 2018;30(11):1259-1273. DOI: 10.1007/s40520-018-0998-6
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  • Blears EE, Elias JK, Tapking C, et al. Supervised resistance training on functional capacity, muscle strength and vascular function in peripheral artery disease: an updated systematic review and meta-analysis. J Clin Med. 2021 May 19;10(10):2193. DOI: 10.3390/jcm10102193
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  • Hollings M, Mavros Y, Freeston J, et al. The effect of progressive resistance training on aerobic fitness and strength in adults with coronary heart disease: A systematic review and meta-analysis of randomised controlled trials. Eur J Prev Cardiol. 2017 Aug;24(12):1242-59. DOI: 10.1177/2047487317713329
  • Lee J, Lee R, Stone AJ. Combined aerobic and resistance training for peak oxygen uptake, muscle strength, and hypertrophy after coronary artery disease: a systematic review and meta-analysis. J Cardiovasc Transl Res. 2020 Aug;13(4):601-11. DOI: 10.1007/s12265-019-09922-0
  • Li N, Li P, Lu Y, et al. Effects of resistance training on exercise capacity in elderly patients with chronic obstructive pulmonary disease: a meta-analysis and systematic review. Aging Clin Exp Res. 2020 Oct;32(10):1911-22. DOI: 10.1007/s40520-019-01339-8
  • Liao WH, Chen JW, Chen X, et al. Impact of resistance training in subjects with COPD: a systematic review and meta-analysis. Respir Care. 2015 Aug;60(8):1130-45. DOI: 10.4187/respcare.03598
  • Oliver-Martínez PA, Ramos-Campo DJ, Martínez-Aranda LM, et al. Chronic effects and optimal dosage of strength training on SBP and DBP: a systematic review with meta-analysis. J Hypertens. 2020 Oct;38(10):1909-18. DOI: 10.1097/hjh.0000000000002459
  • Parmenter BJ, Mavros Y, Ritti Dias R, et al. Resistance training as a treatment for older persons with peripheral artery disease: a systematic review and meta-analysis. Br J Sports Med. 2020 Apr;54(8):452-61. DOI: 10.1136/bjsports-2018-100205
  • Polito MD, Dias JR, Jr., Papst RR. Resistance training to reduce resting blood pressure and increase muscle strength in users and non-users of anti-hypertensive medication: A meta-analysis. Clin Exp Hypertens. 2021 Jul 4;43(5):474-85. DOI: 10.1080/10641963.2021.1901111
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  • Carneiro L, Afonso J, Ramirez-Campillo R, et al. The effects of exclusively resistance training-based supervised programs in people with depression: a systematic review and meta-analysis of randomized controlled trials. Int J Environ Res Public Health. 2020 Sep 15;17(18). DOI: 0.3390/ijerph17186715
  • Coelho-Junior H, Marzetti E, Calvani R, et al. Resistance training improves cognitive function in older adults with different cognitive status: a systematic review and Meta-analysis. Aging Ment Health. 2022 Feb;26(2):213-24. DOI: 10.1080/13607863.2020.1857691
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